344 TNFα-induced vascular hyperpermeability as the possible cause of purpura in drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS)
نویسندگان
چکیده
DIHS/DRESS is a severe adverse drug reaction characterized by persistent eruption associated with reactivation of herpesviruses. In acute phase the disease, purpura occasionally observed mainly in limbs. We recently demonstrated that area lower limbs correlates severity as assessed score. However, pathogenesis has not been examined. collected four patients DIHS and two erythema multiforme (EM). all DIHS, we on at our initial examination performed skin biopsy from purpura. To investigate whether endothelial cell death extravasation erythrocyte, TUNEL assay combined immunohistochemical staining CD31 specimens. addition, measured total 48 human cytokines Bio-Plex Pro Human Cytokine Screening Panel using sera 3 to examine level are involved vascular hyperpermeability. The number TUNEL-positive cells dermis most frequently 400×magnification was higher specimens (n=8,7,6,6), than EM (n=3,1). were matched CD31-positive cells. levels TNFα which reported increase permeability, those healthy controls (65.8±15.3 vs. 42.4±5.1 pg/ml). Our results indicate caused death. Instead, hyperpermeability induced inflammatory such might be cause going perform vitro permeability umbilical vein cultured under serum administration factors DIHS.
منابع مشابه
DRESS Syndrome: Drug Reaction With Eosinophilia and Systemic Symptoms.
DRESS syndrome is a cutaneous and systemic drug reaction with severe complications and a long course that can be fatal. Recognition may be difficult, and the condition is just rare enough that clinicians will eventually see it but may not be familiar with it. This review will focus on key elements to help clinicians with the challenges of recognition and differential diagnosis.
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Drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) involves a unique and severe adverse drug reaction. Patients present with fever, rash, lymphadenopathy, hematological abnormalities, systemic illness, and may suffer from prolonged courses. Although the precise pathogenesis of DRESS/DIHS is not fully understood, it is widely considered...
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BACKGROUND Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is an uncommon but serious hypersensitivity drug reaction most frequently associated with antiepileptics. Clinical manifestations include rash, fever, and visceral organ involvement, most commonly hepatitis. The mortality rate associated with DRESS syndrome is approximately 10%, the majority due to fulminant liver fai...
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BACKGROUND Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially life-threatening acute drug-induced hypersensitivity reaction. Antiepileptic drugs (AEDs) predominantly aromatic AEDs are commonly reported in DRESS. To date there are no reports of sulthiame AED causing DRESS syndrome. METHOD We report a 10-year-old girl of Indian descent with AED resi...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2023
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2023.03.349